hydrogenchloride in methanol 1 h; Heating;

1: 82 percent / glacial acetic acid, conc. H2SO4 / 0.33 h / Heating 2: 1.) t-BuOK / 1.) DMF, RT, 5 min, 2.) DMF, 10 min View Scheme

1: 90 percent / NaN3, conc. H2SO4 / dimethylformamide / 0.42 h / 20 - 80 °C 2: 82 percent / glacial acetic acid, conc. H2SO4 / 0.33 h / Heating 3: 1.) t-BuOK / 1.) DMF, RT, 5 min, 2.) DMF, 10 min View Scheme

potassium tert-butylate 1.) DMF, RT, 5 min, 2.) DMF, 10 min; Multistep reaction;