4-叔丁基-1-甲基-2-硝基苯合成路线 （共 7 条）
反应条件
sulfuric acid; nitric acid
Nitration;
参考文献
Vara Prasad
Organic Letters, 2000 , vol. 2, # 8 p. 1069 - 1072
反应条件
nitrogen trioxide
Oxidation; P=760 Torr; Kinetics;
参考文献
Bolzacchini, Ezio; Meinardi, Simone; Orlandi, Marco; Rindone, Bruno; Hjorth, Jens; Restelli, Gianbattista
Environmental Science and Technology, 1999 , vol. 33, # 3 p. 461 - 468
参考文献
Battegay; Haeffely
Bulletin de la Societe Chimique de France, 1924 , vol. <4> 35, p. 986
反应条件
1: iron; aqueous HCl
2: H2SO4; NaNO2
3: CrO3; acetic acid
View Scheme
参考文献
Carpenter et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 586,606
反应条件
1: permanganate; aqueous pyridine
2: iron (II)-sulfate; diluted ammonia
View Scheme
参考文献
Battegay; Haeffely
Bulletin de la Societe Chimique de France, 1924 , vol. <4> 35, p. 986
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; 18 h;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 35; 49-50 ;
WO 2007/000582 A1
反应条件
H2; nitronium tetrafluoroborate powder in dichloromethane; N,N-dimethyl-formamide; acetonitrile; Petroleum ether
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6492393 B1, 2002 ;
