2,5,6-三氟吡啶-3,4-二胺合成路线 （共 9 条）
反应条件
hydrogen; nickel in ethanol
P=1861.73 Torr; 2 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 13; Figure 2 ;
反应条件
1: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 40 percent / conc. H2SO4 / 18 h / 20 °C
3: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 40 percent / conc. H2SO4 / 18 h / 20 °C
4: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 40 percent / conc. H2SO4 / 18 h / 20 °C
5: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 40 percent / conc. H2SO4 / 18 h / 20 °C
2: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
in diethyl ether
0 °C, 4 h, dry ether;; chromatography;;
参考文献
Chambers,R.D. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 220 - 224
Full Text View citing articles Show Details
National Research Development Corp.
Patent: GB1159036 , 1969 ;
C.A., 1969 , vol. 71, p. 101727
反应条件
diethoxymethyl acetate
T=100°C; 1 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 13; 14; Figure 2 ;
反应条件
1: 28 percent / 1 h / 100 °C
2: 0.25 g / CF3SO3Si(CH3)3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
