反应条件
1: K2CO3 / methanol / 1 h / 50 °C
2: p-toluenesulfonic acid / CH2Cl2 / 0.33 h / 25 °C
3: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 20 deg C, 30 min
View Scheme
参考文献
Hayashi, Masaki; Arai, Yoshinobu; Wakatsuka, Hirohisa; Kawamura, Masanori; Konishi, Yoshitaka; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 525 - 535
