1: 3,5-dibromopyrazine-2-ylamine With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=20°C; 0.5 h; 2: 4-fluorophenyl boronic acid With sodium carbonate in ethylene glycol dimethyl ether; water T=100°C; 5 h;

bis(benzonitrile)palladium(II) dichloride; sodium carbonate; 1,4-di(diphenylphosphino)-butane in ethanol; water; toluene Suzuki coupling; 7 h; Heating;