反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: pyridine; hydroxylamine hydrochloride / methanol / 2 h / Reflux
3.1: pyridine / dichloromethane / 12 h / 20 °C / Cooling with ice
4.1: ammonia / methanol; dichloromethane / 48 h / -50 - 20 °C
4.2: -20 °C
View Scheme
参考文献
Savechenkov, Pavel Y.; Zhang, Xi; Chiara, David C.; Stewart, Deirdre S.; Ge, Rile; Zhou, Xiaojuan; Raines, Douglas E.; Cohen, Jonathan B.; Forman, Stuart A.; Miller, Keith W.; Bruzik, Karol S.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6554 - 6565
