1: n-BuLi / tetrahydrofuran / -78 °C / addition of 2,6-dibromopyridine to a solution of BuLi
2: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C / addition of 2,6-dibromopyridine into a solution of dilithiopyridine
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参考文献
UCB S.A.
Patent: WO2006/114606 A1, 2006 ;
Location in patent: Page/Page column 75-76 ;
WO 2006/114606 A1
1: 2,6-Dibromopyridine With n-butyllithium in tetrahydrofuran; hexane
T=-76 - -60°C;
2: acetone in tetrahydrofuran; hexane
T=20°C; Cooling with dry ice;
3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/131814 A2, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/131814 A2
