2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
1: sulfuric acid; nitric acid / 20 °C 2: N,N-dimethyl-formamide / 80 - 140 °C 3: acetic acid; zinc / 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 52, p. 205 - 212
反应条件
in water T=20°C; pH 8.6; Rate constantEquilibrium constant;
参考文献
Steenken; Telo; Novais; Candeias
Journal of the American Chemical Society, 1992 , vol. 114, # 12 p. 4701 - 4709
反应条件
1: 1) NaOH, (NH4)2S2O8 2) H2SO4 / 1) water, 5 h, 20 deg C 2) 2 h, 85 deg C 2: 84 percent / Me3SiCl / dioxane / Heating View Scheme
参考文献
Tolstikov, G. A.; Sharipova, F. V.; Baltina, L. A.; Spirikhin, L. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 9 p. 1030 - 1032
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , vol. 26, # 9 p. 1235 - 1237
反应条件
1: 24 percent / potassium persulfate / aq. NaOH / Ambient temperature 2: 78 percent / 10percent H2SO4 / 0.17 h / 85 - 90 °C 3: 81 percent / 9 h 4: 84 percent / POCl3/dimethylaniline / 2 h / Heating 5: 83 percent / KOH / Raney nickel / aq. ethanol / 2 h / Heating View Scheme
参考文献
Gashev, S. B.; Gol'tsova, L. V.; Smirnov, L. D.; Lezina, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 5 p. 530 - 535
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 5 p. 636 - 640
反应条件
sodium hydroxide Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Krivonogov, V. P.; Tolstikov, G. A.; Murinov, Yu. I.; Zarudii, F. S.; Lazareva, D. N.; et al.
Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 11 p. 776 - 779
Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 11 p. 41 - 44
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran T=25°C; 2: With ammonium formate; palladium on activated charcoal in methanol Heating;
参考文献
Lopez; Arias; Chan; Clarke; Elworthy; Ford; Guzman; Jaime-Figueroa; Jasper; Morgans Jr.; Padilla; Perez-Medrano; Quintero; Romero; Sandoval; Smith; Williams; Blue
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 11 p. 1873 - 1878
参考文献
Wheeler; McFarland
American Chemical Journal, 1909 , vol. 42, p. 108
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Hoebel
Justus Liebigs Annalen der Chemie, 1907 , vol. 353, p. 250
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Hagen
Justus Liebigs Annalen der Chemie, 1888 , vol. 244, p. 15
反应条件
chlorine in chloroform T=20°C; 2 h;
参考文献
Kasradze; Ignatyeva; Khusnutdinov; Suponitskii, K. Yu.; Antipin, M. Yu.; Yunusov
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 1018 - 1027
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 7 p. 1095 - 1106,12
反应条件
hydrogenchloride; dihydrogen peroxide in water T=20°C;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 48, # 7 p. 1018 - 1027
Khim. Geterotsikl. Soedin., , vol. 48, # 7 p. 1095 - 1106,12
反应条件
1: 75 percent / KNO3; H2SO4 2: 60 percent / POCl3; PhNEt2 / Heating View Scheme
参考文献
Sura, Mallikarjun Reddy; Peddiahgari, Vasu Govardhana Reddy; Bhoomireddy, Rajendra Prasad Reddy; Vadde, Rama Krishna
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1395 - 1399
