2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
sulfuric acid; nitric acid T=0°C;
参考文献
CYTOPIA RESEARCH PTY LTD
Patent: WO2009/62258 A1, 2009 ;
Location in patent: Page/Page column 97-98 ;
WO 2009/062258 A1
反应条件
barium dihydroxide in water T=20°C; 24 h;
参考文献
Lu, Xiao; Chen, Yanli; Guo, Ying; Liu, Zhenming; Shi, Yawei; Xu, Yang; Wang, Xiaowei; Zhang, Zhili; Liu, Junyi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 23 p. 7399 - 7407
反应条件
2: aq. NaOH solution View Scheme
参考文献
Endicott; Johnson
Journal of the American Chemical Society, 1941 , vol. 63, p. 2063
反应条件
dihydrogen peroxide; acetic acid; potassium iodide T=20 - 25°C; Reagent/catalystSolventConcentrationTime;
参考文献
Kasradze; Ignatyeva; Khusnutdinov; Suponitskii, K. Yu.; Antipin, M. Yu.; Yunusov
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 1018 - 1027
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 7 p. 1095 - 1106,12
反应条件
nachfolgend Oxydation mit Chromsaeure;
参考文献
Behrend; Gruenewald
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 196
反应条件
1: 72 percent / SeO2, gl. acetic acid / 24 h / Heating 2: pyridinium tosylate / methanol / 36 h / Heating 3: 5percent aq. KOH / 0.25 h / 50 °C 4: 80percent aq. acetic acid, 2 N HCl / 1 h / 70 °C 5: 50 percent / tetrahydrofuran / 0.5 h / -20 °C View Scheme
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
参考文献
Mahesh; Kumar; Prakash
Journal of the Indian Chemical Society, 1982 , vol. 59, # 10 p. 1192 - 1193
反应条件
1: 76.4 percent / KOH / 73 h / 50 °C 2: 60.1 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 63, # 11 p. 2523 - 2536
反应条件
1: 88 percent / SeO2; acetic acid / Heating 2: 88 percent / NaBH4 / methanol 3: 93 percent / thionyl chloride / CH2Cl2 / Heating View Scheme
参考文献
Sun, Lingyi; Li, Jiarong; Bera, Hriday; Dolzhenko, Anton V.; Chiu, Gigi N.C.; Chui, Wai Keung
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 400 - 410
反应条件
oxygen; ozone in water T=37°C; 2 h;
参考文献
Matsui, Masaki; Nakazumi, Hiroyuki; Kamiya, Kazusaki; Yatome, Chizuko; Shibata, Katsuyoshi; Muramatsu, Hiroshige
Chemistry Letters, 1989 , p. 723 - 724
