2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
参考文献
Behrend; Bueckendorff
Justus Liebigs Annalen der Chemie, 1911 , vol. 385, p. 316
反应条件
copper(l) iodide; sodium acetate in N,N-dimethyl-formamide
T=40°C; 10 h;
参考文献
Zhou, Tao; Li, Ti-Cong; Chen, Zhen-Chu
Helvetica Chimica Acta, 2005 , vol. 88, # 2 p. 290 - 296
反应条件
copper(l) iodide; potassium carbonate in N,N-dimethyl-formamide
T=40°C; 6 h; Product distribution; Further Variations:ReagentsSolvents;
参考文献
Zhou, Tao; Li, Ti-Cong; Chen, Zhen-Chu
Helvetica Chimica Acta, 2005 , vol. 88, # 2 p. 290 - 296
反应条件
1: 72 percent / SeO2, gl. acetic acid / 24 h / Heating
2: pyridinium tosylate / methanol / 36 h / Heating
3: 5percent aq. KOH / 0.25 h / 50 °C
View Scheme
参考文献
Botta; De Angelis; Corelli; Menichincheri; Nicoletti; Marongiu; Pani; La Colla
Archiv der Pharmazie, 1991 , vol. 324, # 4 p. 203 - 207
反应条件
sodium hydroxide in water
T=25°C; 72 h;
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
参考文献
Behrens, Guenter; Hildenbrand, Knut; Schulte-Frohlinde, Dietrich; Herak, Janko N.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 305 - 318
参考文献
Saladino, Raffaele; Danti, Maria Chiara; Mincione, Enrico; Crestini, Claudia; Palamara, Anna Teresa; Savini, Patrizia; Marini, Stefano; Botta, Maurizio
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1833 - 1838
反应条件
potassium carbonate in dimethyl sulfoxide
15 h;
参考文献
Kusmierek, Jaroslav; Kaeppi, Rainer; Neuvonen, Kari; Shugar, David; Loennberg, Harri
Acta Chemica Scandinavica, 1989 , vol. 43, # 2 p. 196 - 202
反应条件
1: aqueous-alcoholic KOH-solution
View Scheme
参考文献
Behrend; Thurm
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 165
反应条件
in ethylene glycol
T=140 - 160°C;
参考文献
Roth; Strelitz; Rauckmann
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 379 - 384
