2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
1: acetic acid; N-iodo-succinimide / 7 h
2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / ethyl acetate / 16 h / 10 - 25 °C / Inert atmosphere
View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
WO 2011/019405 A1
反应条件
1: H2O2; aqueous HCl
2: acetic acid anhydride
View Scheme
参考文献
Sun, Lingyi; Li, Jiarong; Bera, Hriday; Dolzhenko, Anton V.; Chiu, Gigi N.C.; Chui, Wai Keung
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 400 - 410
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=65 - 70°C; 72 h; Product distribution / selectivity;
参考文献
ADENOSINE THERAPEUTICS, LLC
Patent: WO2008/27585 A2, 2008 ;
Location in patent: Page/Page column 34 ;
WO 2008/027585 A2
参考文献
Behrend; Bueckendorff
Justus Liebigs Annalen der Chemie, 1911 , vol. 385, p. 316
反应条件
1: phosphoroxychloride
3: N-bromosuccinimide
View Scheme
参考文献
Yanai
Yakugaku Zasshi, 1942 , vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
Chem.Abstr., 1951 , p. 5150
反应条件
1: trichlorophosphate / 3 h / 105 °C
2: potassium hydroxide / water / 6 h / 20 °C
View Scheme
参考文献
Kanatomo; Wada; Yomei; Hase; Nagai; Fukuda; Tanaka; Sasaki
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2042 - 2049
反应条件
sodium methylate; N,N-dimethyl-aniline; trichlorophosphate
1.) 100 deg C, 3 h, 2.) 0 deg C, 2 h; reflux, 3 h; Yield given. Multistep reaction;
参考文献
Wada; Yasuda; Kanatomo
Synthesis, 1988 , # 10 p. 771 - 775
反应条件
phosphorus pentachloride; trichlorophosphate
T=125°C; im Rohr;
参考文献
Behrend
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 17
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 249
参考文献
Behrend
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 17
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 249
参考文献
Endicott; Johnson
Journal of the American Chemical Society, 1941 , vol. 63, p. 2063
