2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
selenium(IV) oxide; acetic acid Heating;
参考文献
Kalman, Thomas I.; Lai, Li
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 367 - 373
反应条件
1: 80 percent / Ba(OH)2*8H2O / H2O / 24 h / 20 °C 2: 80 percent / HCl / H2O / 1 h / Heating View Scheme
参考文献
Chen, Yanli; Guo, Ying; Yang, Hua; Wang, Xiaowei; Liu, Junyi
Synthetic Communications, 2006 , vol. 36, # 19 p. 2913 - 2920
反应条件
1: 83 percent / conc. H2SO4, fuming HNO3 (d 1.5) / 0 °C 2: 91 percent / fuming HNO3 (d 1.5) / 4 h / 100 °C 3: 97 percent / conc. H2SO4 / 9 h / Heating 4: 74 percent / POCl3, PhNMe2 / 1.) 30 min, 2.) reflux, 1 h View Scheme
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
potassium hydroxide in ethanol; water Heating;
参考文献
Krivonogov; Myshkin; Kozlova; Chernyshenko; Savlukov; Plechev; Ibatullina; Abdrakhmanov; Spirikhin
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 11 p. 1711 - 1714
反应条件
1: 88 percent / SeO2; acetic acid / Heating 2: 88 percent / NaBH4 / methanol View Scheme
参考文献
Sun, Lingyi; Li, Jiarong; Bera, Hriday; Dolzhenko, Anton V.; Chiu, Gigi N.C.; Chui, Wai Keung
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 400 - 410
反应条件
1: 75 percent / KNO3; H2SO4 2: 60 percent / POCl3; PhNEt2 / Heating 3: 35 percent / methanol View Scheme
参考文献
Hodgetts, Kevin J.; Yoon, Taeyoung; Huang, Jianhua; Gulianello, Michael; Kieltyka, Andrzej; Primus, Renee; Brodbeck, Robbin; De Lombaert, Stephane; Doller, Dario
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2497 - 2500
反应条件
sulfuric acid durch elektrolytische Reduktion;
参考文献
Tafel; Weinschenk
Chemische Berichte, 1900 , vol. 33, p. 3370
反应条件
1: phosphorus oxychloride 2: zinc dust; water View Scheme
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 1533,2930, 2934
反应条件
2: phosphoroxychloride View Scheme
参考文献
Kanatomo; Wada; Yomei; Hase; Nagai; Fukuda; Tanaka; Sasaki
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 2042 - 2049
反应条件
1: 93 percent / TBAF / 8 h 2: 55.7 percent / ammonium formate / 10percent Pd/C / methanol / 8 h / Heating View Scheme
参考文献
Botta; Summa; Saladino; Nicoletti
Synthetic Communications, 1991 , vol. 21, # 21 p. 2181 - 2187
