4-羟基-2-氧代-1-吡咯烷乙酸乙酯合成路线 （共 9 条）
反应条件
sodium hydroxide in water 3 h; Ambient temperature;
参考文献
Banfi, S.; Fonio, W.; Allievi, E.; Pinza, M.; Dorigotti, L
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 1 p. 16 - 22
参考文献
ISF Societa Per Azioni
Patent: US4824861 A1, 1989 ;
反应条件
sodium borohydride in ethylene glycol dimethyl ether; chloroform
参考文献
Lonza Ltd.
Patent: US4824966 A1, 1989 ;
反应条件
in ethanol; cyclohexane; water; sodium chloride
参考文献
Lonza Ltd.
Patent: US5276164 A1, 1994 ;
反应条件
methyltrichloromonosilane; sodium iodide in acetonitrile
Heating9 + 2 h;
参考文献
Laffan; Banziger; Duc; Evans; McGarrity; Meul
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 892 - 900
反应条件
1: 58.8 g / HCl, H2O (cat. quantity) / acetic acid / 16 h / 40 °C
2: H2 / 5percent Ru/C / 23 h / 18751.5 Torr
View Scheme
参考文献
Laffan; Banziger; Duc; Evans; McGarrity; Meul
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 892 - 900
反应条件
hydrogen; Ru-carbon
P=18751.5 Torr; 23 h; Yield given;
参考文献
Laffan; Banziger; Duc; Evans; McGarrity; Meul
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 892 - 900
反应条件
hydrogenchloride; sodium hydride
1.) acetonitrile, mineral oil, reflux, 30 min; 2.) 15 min; Yield given. Multistep reaction;
参考文献
Pellegata; Pinza; Pifferi; Gaiti; Mozzi; Tirillini; Porcellati
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 10 p. 845 - 855
