1: 4-bromo-1,1'-biphenyl With magnesium in tetrahydrofuran 1 h; Inert atmosphereReflux; 2: (S)-(+)-1-bromo-2-methylbutane With dilithium tetrachlorocuprate in tetrahydrofuran 48 h; RefluxInert atmosphere;

1: 24.5 g / pyridine / 1 h / 0 - 5 °C 2: 70 percent / lithium bromide / acetone / Ambient temperature 3: 1.) magnesium, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride / 1.) ether, 2.) ether, reflux, 5 h View Scheme

1: 70 percent / lithium bromide / acetone / Ambient temperature 2: 1.) magnesium, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride / 1.) ether, 2.) ether, reflux, 5 h View Scheme

[1,3-bis(diphenylphosphino) propane] dichloronickel(II); magnesium 1.) ether, 2.) ether, reflux, 5 h; Yield given. Multistep reaction;