4′-羟基-3′-碘苯乙酮合成路线 （共 12 条）
反应条件
dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=140°C; Inert atmosphere;
参考文献
Oberholzer, Miriam; Gerber, Roman; Frech, Christian M.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 627 - 641
反应条件
1: CsF / acetonitrile / 10 h / 20 °C 2: tricyclohexylphosphine / Pd(OAc)2 / acetonitrile / 24 h / 100 °C View Scheme
参考文献
Liu, Zhijian; Larock, Richard C.
Tetrahedron, 2007 , vol. 63, # 2 p. 347 - 355
反应条件
tetrabutyl-ammonium chloride; sodium acetate; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=100°C; 24 h; Yield given. Yields of byproduct given;
参考文献
Larock, Richard C.; Berrios-Pena, Norman; Narayanan, Kris
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3447 - 3450
反应条件
trichloroisocyanuric acid; iodine in dichloromethane
T=20°C;
参考文献
Akhlaghinia, Batool; Rahmani, Marzieh
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 1 p. 3 - 6
反应条件
sodium hypochlorite; sodium iodide in methanol
T=15°C; 1 h;
参考文献
Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru
Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
反应条件
dihydrogen peroxide; iodine in water
T=20°C; 24 h;
参考文献
Gallo, Rafael D.C.; Gebara, Karimi S.; Muzzi, Rozanna M.; Raminelli, Cristiano
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 4 p. 770 - 774
反应条件
aluminium trichloride; nitrobenzene
参考文献
Chen; Tsai
Taiwan Yaoxue Zazhi, 1952 , vol. 4, p. 42,43
反应条件
Pd-Cu/C; ethanolamine; triphenylphosphine in water
T=80°C; 20 h; Sealed tubeInert atmosphere;
参考文献
Rossy, Cybille; Fouquet, Eric; Felpin, Francois-Xavier
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1426 - 1431
反应条件
copper(l) iodide; palladium; triphenylphosphine; aluminum oxide; potassium fluoride
Sonogashira coupling-cyclization; 0.0583333 h; microwave irradiation (100 percent power);
参考文献
Kabalka, George W.; Wang, Lei; Pagni, Richard M.
Tetrahedron, 2001 , vol. 57, # 38 p. 8017 - 8028
反应条件
1: 87 percent / K2CO3 / acetone / 0.67 h / Heating
2: 90 percent / PPh3, CuI / PdCl2 / triethylamine; dimethylformamide / 0.8 h / 85 °C
3: 91 percent / K2CO3 / ethanol / 1.5 h / Heating
4: 90 percent / 47percent HBr / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru
Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
