5-羟基-2-(甲基氨基)[1,3]噻唑并[4,5-b]吡啶-7(4H)-酮合成路线 （共 1 条）
反应条件
1: Carbamonitrile; isothiocyanatomethane With potassium hydroxide in ethanol
T=20°C; 1 h;
2: ethyl alpha-chloroacetoacetate With potassium hydroxide in ethanol
0.5 h; Reflux;
3: With hydrogenchloride in ethanol; water
T=20°C; pH=7; regioselective reaction;
参考文献
Shestopalov, Anatoliy M.; Rodinovskaya, Liudmila A.; Shestopalov, Alexander A.
Tetrahedron, 2010 , vol. 66, # 46 p. 8945 - 8948
