2-噻吩-2-甲基-苯甲酸合成路线 （共 3 条）
反应条件
ammonium hydroxide; zinc
Heating;
参考文献
Tedjamulia, Marvin L.; Tominaga, Yoshinori; Castle, Raymond N.; Lee, Milton L.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1143 - 1148
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
2 h; Heating;
参考文献
Sabitha, Gowravaram; Yadav
Synthetic Communications, 1998 , vol. 28, # 16 p. 3065 - 3071
反应条件
1.1: AlCl3 / CH2Cl2 / 0.5 h / 20 °C
1.2: 70 percent / CH2Cl2 / 3 h / 20 °C
2.1: 60 percent / aq. NH3; CuSO4; Zn / 48 h / Heating
View Scheme
参考文献
Zuse, Anne; Schmidt, Peter; Baasner, Silke; Boehm, Konrad J.; Mueller, Klaus; Gerlach, Matthias; Guenther, Eckhard G.; Unger, Eberhard; Prinz, Helge
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7816 - 7825
