N-(2-羟乙基)烟酰胺合成路线 （共 12 条）
反应条件
1: [3H]-Nicotinic acid With thionyl chloride in toluene T=140°C; 4 h; 2: ethanolamine in toluene T=50°C;
参考文献
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
Patent: WO2006/92204 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
参考文献
University of Florida
Patent: US5017566 A1, 1991 ;
反应条件
T=150 - 160°C; Condensation; 3 h;
参考文献
Kniess; Spies; Brandau; Johannsen
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 7 p. 605 - 614
反应条件
hydrogenchloride in water T=100°C; 0.5 h;
参考文献
Journal of the Chinese Chemical Society, , vol. 55, # 6 p. 1357 - 1366
反应条件
1: H2SO4 / cyclohexane / Heating 2: CHCl3 / 4 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 6 p. 808 - 816
参考文献
Journal of the American Chemical Society, , vol. 69, p. 200,203
反应条件
T=60°C; 7 h; variation of pH; Δ Eexcit; Rate constantMechanismThermodynamic data;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 3 p. 1063 - 1070
反应条件
1: With nitric acid; acetic anhydride; acetic acid T=15 - 22°C; Inert atmosphere; 2: With ammonia in water T=5 - 35°C; 1 h; Product distribution / selectivity;
参考文献
WO2012/89769 A1, ;
Page/Page column 9-10 ;
反应条件
Product distribution / selectivity;
参考文献
TERNANSKY, Robert
Patent: WO2007/38772 A1, 2007 ;
Location in patent: Example 3 ;
WO 2007/038772 A1
反应条件
hydrogenchloride; ethanol
参考文献
Phillips; Baltzly
Journal of the American Chemical Society, 1947 , vol. 69, p. 200,203
