A-氧代-1H-吡咯并[2,3-B]吡啶-3-乙酸合成路线 （共 3 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=20°C;
参考文献
Ganser, Christopher; Lauermann, Eva; Maderer, Annett; Stauder, Torsten; Kramb, Jan-Peter; Plutizki, Stanislav; Kindler, Thomas; Moehler, Markus; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9531 - 9540
反应条件
ethylmagnesium bromide in tetrahydrofuran T=70°C; 1.5 h;
参考文献
O'Neill, David J.; Shen, Lan; Prouty, Catherine; Conway, Bruce R.; Westover, Lori; Xu, Jun Z.; Zhang, Han-Cheng; Maryanoff, Bruce E.; Murray, William V.; Demarest, Keith T.; Kuo, Gee-Hong
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 12 p. 3167 - 3185
反应条件
1.1: trifluoroacetic acid; triethylsilane / 16 h / 20 - 55 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C 2.2: 0 °C / pH 5 View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
WO 2012/009678 A1
