2-溴-5-甲氧基-1,3-二甲苯合成路线 （共 28 条）
反应条件
hydrogenchloride in tetrahydrofuran; water; N,N-dimethyl-formamide; pentane
参考文献
The Regents of the University of California
Patent: US6107517 A1, 2000 ;
参考文献
Zimmerman,H.E.; Paskovich,D.H.
Journal of the American Chemical Society, 1964 , vol. 86, p. 2149 - 2160
反应条件
aluminium trichloride
参考文献
v. Auwers
Justus Liebigs Annalen der Chemie, 1920 , vol. 421, p. 57
参考文献
v. Auwers
Justus Liebigs Annalen der Chemie, 1920 , vol. 421, p. 57
反应条件
1: 92 percent / NBS; AIBN / CCl4 / 4 h / Heating
2: 95 percent / aq. calcium carbonate / dioxane / 10 h / Heating
3: 85 percent / aq. KMnO4 / acetone / 0.5 h / Heating
4: thionyl chloride / 3 h / Heating
5: 8.8 g / pyridine / 2 h / 20 °C
View Scheme
参考文献
Holzwarth, Richard; Bartsch, Richard; Cherkaoui, Zoubair; Solladie, Guy
Chemistry - A European Journal, 2004 , vol. 10, # 16 p. 3931 - 3935
反应条件
PEPPSITM-IPr in tetrahydrofuran; 1,3-dimethyl-imidazolidin-2-one
T=60°C; Negishi cross-coupling; 24 h; Inert atmosphere;
参考文献
Nasielski, Joanna; Hadei, Nilofaur; Achonduh, George; Kantchev, Eric Assen B.; O'Brien, Christopher J.; Lough, Alan; Organ, Michael G.
Chemistry - A European Journal, 2010 , vol. 16, # 35 p. 10844 - 10853
反应条件
1: Li / tetrahydrofuran / 1 h
2: NaBH4 / methanol / 0 °C
3: 73 percent / PPh3; CBr4 / Pd2(dba)3 / CH2Cl2 / 0.5 h / 0 - 20 °C
View Scheme
参考文献
Srikrishna; Ravi Kumar; Padmavathi
Synlett, 2002 , # 11 p. 1907 - 1909
反应条件
n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
Tatsuta, Kuniaki; Tanaka, Hiroaki; Tsukagoshi, Hitomi; Kashima, Takafumi; Hosokawa, Seijiro
Tetrahedron Letters, 2010 , vol. 51, # 42 p. 5546 - 5549
