1-(4-硝基苯基)哌嗪合成路线 （共 39 条）
反应条件
triethylamine in dichloromethane
参考文献
US2004/87575 A1, ;
US 20040087575 A1
反应条件
1: triethylamine / dichloromethane / 1 h / 0 - 5 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 20 °C View Scheme
参考文献
WO2012/59932 A1, ;
WO 2012/059932 A1
反应条件
triethylamine in acetone T=20°C; 24 h;
参考文献
Pessoa-Mahana, David; Nunez, Andres; Espinosa, Christian; Mella-Raipan, Jaime; Pessoa-Mahana, Hernan
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 1 p. 63 - 70
反应条件
acetic anhydride; triethylamine in dichloromethane
参考文献
Pierson, Edward; Sohn, Daniel; Haeberlein, Markus; Davenport, Timothy; Chapdelaine, Marc; Horchler, Carey; McCauley, John P.
Patent: US2003/13708 A1, 2003 ;
Title/Abstract Full Text Show Details
Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel
Patent: US2004/110745 A1, 2004 ;
US 20040110745 A1
反应条件
1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 5 h / 20 °C View Scheme
参考文献
Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 771 - 783
反应条件
NH2NH2•xH2O T=90°C; 1.66667 h; chemoselective reaction;
参考文献
Yadav, Veena; Gupta, Shweta; Kumar, Rupesh; Singh, Gajendra; Lagarkha, Rekha
Synthetic Communications, 2012 , vol. 42, # 2 p. 213 - 222
反应条件
1.1: 95 percent / NH4O2CH / Pd/C / methanol / Heating 2.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 3.1: NaNO2; H2SO4 3.2: 48 percent / Cu(NO3)2; Cu2O / H2O 4.1: 82 percent / NH4HCO2 / Pd/C / ethyl acetate / Heating View Scheme
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
1.1: 95 percent / NH4O2CH / Pd/C / methanol / Heating 2.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 3.1: NaNO2; H2SO4 3.2: 48 percent / Cu(NO3)2; Cu2O / H2O View Scheme
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
in water; N,N-dimethyl-formamide 1) heating, 10 min, 2) r.t., overnight;
参考文献
Agarwal
Journal of the Indian Chemical Society, 1991 , vol. 68, # 2 p. 85 - 87
反应条件
in N-methyl-acetamide
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;
