2-甲基-5-硝基苯磺酰胺合成路线 （共 5 条）
反应条件
ammonium hydroxide in diethyl ether T=0°C; 42 h; Inert atmosphere;
参考文献
ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep
Patent: WO2012/48222 A1, 2012 ;
Location in patent: Page/Page column 98 ;
WO 2012/048222 A1
反应条件
1: With chlorosulfonic acid T=60°C; 48 h; 2: With ammonium hydroxide in diethyl ether T=50°C; 2 h;
参考文献
Zhang, Shenyi; Yang, Chunmei; Lu, Weiqiang; Huang, Jin; Zhu, Weiping; Li, Honglin; Xu, Yufang; Qian, Xuhong
Chemical Communications, 2011 , vol. 47, # 29 p. 8301 - 8303
反应条件
1: 56 percent / CrO3, conc. H2SO4 / H2O / 24 h / Ambient temperature 2: 63 percent / cyclohexene / 5percent Pd/C / ethanol / 2 h / Heating View Scheme
参考文献
Gener, Nahit; Demir, Dudu; Sonmez, Fatih; Kucukislamoglu, Mustafa
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2811 - 2821
反应条件
1: With hydrogenchloride; tin(ll) chloride in diethylene glycol dimethyl ether; water T=0°C; 0.75 h; 2: With sodium hydroxide; sodium hydrogencarbonate in diethyl ether; diethylene glycol dimethyl ether; water
参考文献
SMITHKLINE BEECHAM CORPORATION; KUMAR, Rakesh
Patent: WO2005/105094 A2, 2005 ;
Location in patent: Page/Page column 33-34 ;
反应条件
chromium(VI) oxide; sulfuric acid in water T=20°C; 24 h;
参考文献
Gener, Nahit; Demir, Dudu; Sonmez, Fatih; Kucukislamoglu, Mustafa
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2811 - 2821
