反应条件
1.1: methanol; sodium hydride / toluene; mineral oil / 3.5 h / 60 °C / Inert atmosphere
2.1: potassium carbonate / acetone / 12 h / Reflux; Inert atmosphere
3.1: methanol; sodium methylate / 3 h / Reflux; Inert atmosphere
3.2: 3 h / Reflux; Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
4.2: 0 °C / Inert atmosphere
5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 9 h / 0 - 20 °C / Inert atmosphere
6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / 0 °C / Inert atmosphere
7.1: potassium hydroxide / methanol; water / 8 h / 60 °C
7.2: 20 °C / pH 1
8.1: sulfuric acid / dichloromethane; water / 16 h / 0 °C
View Scheme
参考文献
Abraham, Elin; Claridge, Timothy D.W.; Davies, Stephen G.; Odell, Barbara; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Smith, Lorna J.; Storr, Helen R.; Sweet, Miles J.; Thompson, Amber L.; Thomson, James E.; Tranter, George E.; Watkin, David J.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 69 - 100
