4-氯-2,6-二甲基喹啉合成路线 （共 7 条）
反应条件
hydrogenchloride; ethanol; water und Zinn;
参考文献
Alekseewa
Promysl. org. Chim., 1937 , vol. 4, p. 23,26
Chem. Zentralbl., 1939 , vol. 110, # I p. 1759
反应条件
phosphorus pentachloride in Phosphoroxy chloride
参考文献
Alkaloide Vegyeszeti Gyar
Patent: US4599345 A1, 1986 ;
反应条件
N,N-dimethyl-aniline; trichlorophosphate in toluene
T=90°C; 3.5 h;
参考文献
Warner; Barker; Jackman; Burrows; Roberts; Bishop; O'Connor; Hughes
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2761 - 2768
参考文献
Desai, Geeta; Desai, K. K.; Desai, C. M.
Journal of the Indian Chemical Society, 1987 , vol. 64, # 6 p. 370 - 371
反应条件
1: methanol / 7 h / 40 °C
2: diphenylether / 0.5 h / |Reflux
3: trichlorophosphate / 3 h / |Reflux
View Scheme
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
1: diphenylether / 0.5 h / |Reflux
2: trichlorophosphate / 3 h / |Reflux
View Scheme
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
1: polyphosphoric acid / 5 h / 160 °C
2: phosphorus oxychloride
View Scheme
参考文献
Desai, Geeta; Desai, K. K.; Desai, C. M.
Journal of the Indian Chemical Society, 1987 , vol. 64, # 6 p. 370 - 371
