1: N-(3-(4-bromophenoxy)propyl)-N-butylbutan-1-amine With diisobutyl-aluminum chloride; diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran; n-heptane T=-10 - 25°C; 2: 2-butyl-5-(methanesulfonamido)benzofuran-3-carbonyl chloride With CuCN*2LiCl in tetrahydrofuran; n-heptane T=25°C;

1.1: magnesium / tetrahydrofuran / 1 h / Reflux 1.2: 2 h / -78 °C 1.3: 20 °C 2.1: sodium carbonate; sodium lauryl sulfate / palladium dichloride / water; acetone / 60 °C View Scheme