1: With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,4-dioxane; water T=100°C; 4 h; Inert atmosphere; 2: With hydrogenchloride in water pH=~ 7;

sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; Inert atmosphere;

1: 4,6-di-methyl-pyridin-2-ylamine With 1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-40°C; 0.666667 h; 2: formaldehyd With formic acid in water 18 h; Heating;

formic acid in water Eschweiler-Clark methylation; Heating;