N'-三苯基甲基-L-组氨酸甲酯盐酸盐合成路线 （共 11 条）
反应条件
1: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 2: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
hydrogen; palladium on activated charcoal in methanol
T=25°C; P=760 Torr; 2.5 h;
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
piperidine in N,N-dimethyl-formamide
T=20°C; 0.5 h;
参考文献
Lin, Yu-Chung; Liang, Ming-Ren; Lin, Yu-Chen; Chen, Chao-Tsen
Chemistry - A European Journal, 2011 , vol. 17, # 46 p. 13059 - 13067
反应条件
hydrogenchloride; acetic acid
T=20°C; 0.833333 h;
参考文献
Himes, Richard A.; Ga, Young Park; Barry, Amanda N.; Blackburn, Ninian J.; Karlin, Kenneth D.
Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5352 - 5353
反应条件
1: NEt3 / CH2Cl2 / 0 - 20 °C
2: 6.62 g / aq. HCl; CH3COOH / 0.83 h / 20 °C
View Scheme
参考文献
Himes, Richard A.; Ga, Young Park; Barry, Amanda N.; Blackburn, Ninian J.; Karlin, Kenneth D.
Journal of the American Chemical Society, 2007 , vol. 129, # 17 p. 5352 - 5353
反应条件
1: 99 percent / Et3N / benzene / 1 h / 80 °C
2: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C
2: 99 percent / Et3N / benzene / 1 h / 80 °C
3: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 99 percent / SOCl2 / 36 h / 40 °C
2: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C
3: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C
4: 99 percent / Et3N / benzene / 1 h / 80 °C
5: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C
2: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C
3: 99 percent / Et3N / benzene / 1 h / 80 °C
4: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 69 percent / SOCl2 / 15 h / 25 °C
2: 99 percent / Et3N / benzene / 1 h / 80 °C
3: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr
View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
