sodium hydride in ethylene glycol dimethyl ether Inert atmosphere;
参考文献
Choudary, Bernie; Giles, Robert G.; Jovic, Florence; Lewis, Norman; Moore, Steve; Urquhart, Michael
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1927 - 1939
1: With copper(I) bromide in tetrahydrofuran
T=20 - 60°C;
2: With sulfuric acid; water in tetrahydrofuran
0.5 h;
3: With sodium hydroxide in water
pH=8;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2004/2483 A1, 2004 ;
Location in patent: Page/Page column 21-22; 42; 43 ;
WO 2004/002483 A1