6-羟基-2H-苯并呋喃-3-酮合成路线 （共 40 条）
反应条件
1: lithium borohydride / tetrahydrofuran 2: borane-THF / tetrahydrofuran 3: pyridine; dichloromethane 4: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C View Scheme
参考文献
Nguyen, Son T.; Williams, John D.; Majgier-Baranowska, Helena; Li, Bing; Neelagiri, Venugopal R.; Kim, Hwa-Ok; Peet, Norton P.
Synthetic Communications, 2014 , vol. 44, # 9 p. 1307 - 1313
反应条件
methyl (triphenylphosphoranylidene)acetate in xylene
6 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63155 A1, 2004 ;
Location in patent: Page 86 ;
WO 2004/063155 A1
反应条件
in xylenes
6 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 75-76 ;
WO 2005/066136 A1
反应条件
1: hydrazine; aqueous ethanol; potassium hydroxide / 190 °C / Reagens 4: Aethylenglykol
2: diethyl ether; hydrogen chloride / Erwaermen des Reaktionsprodukts mit Wasser
3: sodium acetate; iodine
View Scheme
参考文献
Davies et al.
Journal of the Chemical Society, 1950 , p. 3206,3212
反应条件
potassium hydroxide in methanol
T=60°C; 1 h;
参考文献
Okombi, Sabrina; Rival, Delphine; Bonnet, Sebastien; Mariotte, Anne-Marie; Perrier, Eric; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 329 - 333
反应条件
1: With potassium hydroxide in methanol; water
T=60°C; 1 h;
2: With hydrogenchloride; water in methanol
T=20°C; 4 h;
参考文献
Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971
反应条件
1.1: triethylamine / acetone / 20 °C
2.1: sodium tetrahydroborate / methanol / 20 °C
2.2: 2 h / 20 °C
2.3: 20 °C / Darkness; Inert atmosphere
3.1: dichloromethane / 72 h / 20 °C
4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr
View Scheme
参考文献
SARCODE BIOSCIENCE INC.; ZELLER, James, Robert; VENKATRAMAN, Sripathy; BROT, Elisabeth, C.A.; IYER, Subashree; HALL, Michael
Patent: WO2014/18748 A1, 2014 ;
参考文献
Sharma, Anil; Chibber, S. S.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 275 - 277
反应条件
potassium hydroxide in methanol; water
Reflux;
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
1: With potassium hydroxide in methanol; water
T=60°C; 1 h;
2: With hydrogenchloride; water in methanol
T=20°C; 4 h;
参考文献
Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971
