4 A molecular sieve in dimethyl sulfoxide T=20°C; 24 h;

bipyridine; nickel diacetate in N,N-dimethyl-formamide 20 h; Ambient temperature;

1: 1-chloro-4-ethynylbenzene With aminobenzyl Wang resin; mercury(II) diacetate; diisopropylamine in tetrahydrofuran; dichloromethane T=20°C; Solid phase reaction; amination; 72 h; 2: (trans)-β-nitrostyrene in dichloromethane Solid phase reaction; addition; 6 h; 3: With trifluoroacetic acid in dichloromethane Solid phase reaction; hydrolysis; 0.333333 h;

methanol

hydrogenchloride; zinc in N,N-dimethyl-formamide T=80°C; 1.5 h;

chloroform; bromine

暂无反应条件数据

1: chloroform; bromine 2: potassium acetate; methanol View Scheme