反应条件
1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere 2.1: dipotassium hydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / tetrahydrofuran / 16 h / |Reflux 3.1: sodium hydroxide / methanol / 19 h / 20 - 50 °C / |Inert atmosphere 3.2: 20 °C / pH Ca. 2 / |Inert atmosphere View Scheme
参考文献
St. Laurent, Denis R.; Serrano-Wu, Michael H.; Belema, Makonen; Ding, Min; Fang, Hua; Gao, Min; Goodrich, Jason T.; Krause, Rudolph G.; Lemm, Julie A.; Liu, Mengping; Lopez, Omar D.; Nguyen, Van N.; Nower, Peter T.; O'Boyle, Donald R.; Pearce, Bradley C.; Romine, Jeffrey L.; Valera, Lourdes; Sun, Jin-Hua; Wang, Ying-Kai; Yang, Fukang; Yang, Xuejie; Meanwell, Nicholas A.; Snyder, Lawrence B.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1976 - 1994