3-羟基-2-吡啶甲酸甲酯合成路线 （共 15 条）
反应条件
1: 77 percent / DABCO / dimethylformamide / 4 h / 20 °C 2: 84 percent / diphenyl ether / 1.75 h / 200 - 210 °C 3: 30 percent / aq. Na2CO3 / methanol / 20 h / Heating View Scheme
参考文献
Krapcho; Haydar
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1153 - 1166
反应条件
hydrazine in ethanol
Reflux;
参考文献
GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon
Patent: WO2010/125102 A1, 2010 ;
Location in patent: Page/Page column 108 ;
WO 2010/125102 A1
反应条件
1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: lithium chloride / Pd2(PPh3)2Cl2 / N,N-dimethyl-formamide / 100 °C
2.2: 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ROMINE, Jeffrey Lee
Patent: WO2012/18325 A1, 2012 ;
WO 2012/018325 A1
反应条件
sodium in methanol; water; dimethyl sulfoxide
参考文献
Smith Kline and French Laboratories Limited
Patent: US4083983 A1, 1978 ;
US 4083983 A
反应条件
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2: lithium chloride / Pd2(PPh3)2Cl2 / N,N-dimethyl-formamide / 4 h / 100 °C
3: hydrogen / palladium 10 on activated carbon / ethanol / 1 h / 20 °C
4: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 72 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ROMINE, Jeffrey Lee
Patent: WO2012/18325 A1, 2012 ;
WO 2012/018325 A1
