2-氯甲基-4-甲氧基吡啶盐酸盐合成路线 （共 7 条）
反应条件
thionyl chloride in dichloromethane
2 h;
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 4 h / 100 °C
2: 2 M NaOH / 1 h / 100 °C
3: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 100 percent / K2CO3 / 12 h / Heating
2: 4 h / 100 °C
3: 2 M NaOH / 1 h / 100 °C
4: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 2 M NaOH / 1 h / 100 °C
2: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 98 percent / conc. H2SO4, 65percent HNO3 / 22 h / 95 °C
2: 100 percent / K2CO3 / 12 h / Heating
3: 4 h / 100 °C
4: 2 M NaOH / 1 h / 100 °C
5: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 98percent HNO3 / acetic acid / 33 h / 80 °C
2: NaOMe / 16 h / 40 °C
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
5: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 2 N aq. NaOH / ethanol / 2 h / 50 °C
2: 94 percent / 10percent aq. NaOCl, 6 N aq. NaOH / ethyl acetate / 0.5 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
