2-(4-甲氧基苯基)-2-甲基丙酸甲酯合成路线 （共 8 条）
反应条件
1: LiAlH4 2: SO3, Py, Et3N / dimethylsulfoxide 3: pentane / Irradiation View Scheme
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
反应条件
boron tribromide in dichloromethane T=-78 - 0°C; 1 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19635 A1, 2013 ;
Location in patent: Page/Page column 55 ;
WO 2013/019635 A1
反应条件
potassium tert-butylate in tetrahydrofuran
T=-78 - 20°C; 1 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 87 ;
WO 2013/019682 A1
反应条件
tri-tert-butyl phosphine; LiN(Cy)2; bis(dibenzylideneacetone)-palladium(0) in toluene
T=20°C; 24 h;
参考文献
Jorgensen, Morten; Lee, Sunwoo; Liu, Xiaoxiang; Wolkowski, Joanna P.; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12557 - 12565
反应条件
ZnF2; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Liu, Xiaoxiang; Hartwig, John F.
Journal of the American Chemical Society, 2004 , vol. 126, # 16 p. 5182 - 5191
反应条件
1: 2-methylpropanoic acid methyl ester With sodium hexamethyldisilazane in toluene
T=20°C; 0.166667 h; Inert atmosphere;
2: 1-methoxy-4-chlorobenzene With [P(t-Bu)3Pd(μ-Br)]2 in toluene
T=100°C; 4 h; Inert atmosphere;
参考文献
Hama, Takuo; Hartwig, John F.
Organic Letters, 2008 , vol. 10, # 8 p. 1549 - 1552
参考文献
Bietti, Massimo; Capone, Alberto
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 618 - 629
反应条件
1: With sodium hydroxide in methanesulfonic acid; water
T=20°C; 6 h;
2: With hydrogenchloride in water
pH=4;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 87 ;
WO 2013/019682 A1
