4-溴-2-氟-1-乙烯基苯合成路线 （共 9 条）
反应条件
aluminum oxide; potassium carbonate; (CuOTf)2.C6H6; (S,S)-tBuBOX in chloroform T=0 - 20°C; 24 - 25 h; Product distribution / selectivity;
参考文献
Dube, Daniel; Gallant, Michel; Lacombe, Patrick
Patent: US2007/99951 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
反应条件
MS 4A; [((CH3)2C(C3H3NOC(CH3)3)2)Cu(OSO2CF3)] in tetrahydrofuran T=0 - 20°C; 29 h; Product distribution / selectivity;
参考文献
Dube, Daniel; Gallant, Michel; Lacombe, Patrick
Patent: US2007/99951 A1, 2007 ;
Location in patent: Page/Page column 18-20 ;
反应条件
[((CH3)2C(C3H3NOC(CH3)3)2)Cu(OSO2CF3)] in IPAc T=0 - 20°C; 29 h; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: US2009/105479 A1, 2009 ;
Location in patent: Page/Page column 17-18 ;
反应条件
aluminum oxide; potassium carbonate; (CuOTf)2.C6H6; (S,S)-tBuBOX in chloroform T=0 - 20°C; 24 - 25 h; Product distribution / selectivity;
参考文献
Dube, Daniel; Gallant, Michel; Lacombe, Patrick
Patent: US2007/99951 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
反应条件
[((CH3)2C(C3H3NOC(CH3)3)2)Cu(OSO2CF3)] in IPAc T=0 - 20°C; 29 h; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: US2009/105479 A1, 2009 ;
Location in patent: Page/Page column 17-18 ;
反应条件
zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine in tetrahydrofuran
T=-5 - 20°C; 4.16 - 6.16 h;
参考文献
Dube, Daniel; Gallant, Michel; Lacombe, Patrick
Patent: US2007/99951 A1, 2007 ;
Location in patent: Page/Page column 11-12 ;
反应条件
potassium tert-butylate in diethyl ether
T=20°C; 1 h;
参考文献
Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright
Patent: US2004/6058 A1, 2004 ;
Location in patent: Page/Page column 26 ;
US 20040006058 A1
反应条件
Methyltriphenylphosphonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane
T=20°C; 3 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/21489 A1, 2011 ;
Location in patent: Page/Page column 24-25 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
P=760.051 Torr;
参考文献
Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright
Patent: US2004/6058 A1, 2004 ;
Location in patent: Page/Page column 26 ;
US 20040006058 A1
