2,6-二氯-4-甲基-3-吡啶甲酸合成路线 （共 8 条）
反应条件
sulfuric acid; water; sodium nitrite T=20 - 60°C; 7.25 h;
参考文献
Wang, Yamin; Bullock, William H.; Chen, Libing
Patent: US6677352 B1, 2004 ;
Location in patent: Page/Page column 46 ;
反应条件
sulfuric acid; water; nitric acid T=70 - 105°C; 2 h;
参考文献
Wang, Yamin; Bullock, William H.; Chen, Libing
Patent: US6677352 B1, 2004 ;
Location in patent: Page/Page column 46 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate in water; tert-butyl alcohol T=10 - 25°C; Oxidation; 4 h;
参考文献
Sarkar, Tarun K.; Ghosh, Sunil K.; Chow, Tahsin J.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3111 - 3115
反应条件
1: 98 percent / POCl3 / 6 h / 120 °C 2: 93 percent / aq. H2SO4 / 6 h / 98 °C 3: 88 percent / H2SO4; aq. NaNO2 / 20 - 25 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 3 p. 308 - 314
反应条件
Cyclization; electrocyclization; UV-irradiation;
参考文献
Tetrahedron Letters, , vol. 41, # 35 p. 6909 - 6913
反应条件
1: 2,6-dichloro-4-methyl-nicotinic acid With potassium carbonate in N,N-dimethyl-formamide T=23°C; 30 h; 2: ethyl iodide in N,N-dimethyl-formamide T=23°C; 18 h;
参考文献
GRÜNENTHAL GMBH; LUCAS, Simon; KÜHNERT, Sven; BAHRENBERG, Gregor; SCHRÖDER, Wolfgang; KLESS, Achim
Patent: WO2013/156154 A1, 2013 ;
Location in patent: Page/Page column 49 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Adam, Jean-Michel; Aebi, Johannes; Binggeli, Alferd; Green, Luke; Hartmann, Guido; Maerki, Hans P.; Mattei, Patrizio; Ricklin, Fabienne; Roche, Olivier
Patent: US2009/318467 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: borane-THF / tetrahydrofuran / 6 h / 20 °C / |Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C
View Scheme
参考文献
Li, Xiangmin; Wang, Sinan; Li, Tengfei; Li, Jian; Li, Hao; Wang, Wei
Organic Letters, 2013 , vol. 15, # 22 p. 5634 - 5637
