4-(2-苯并噻唑基)苯胺合成路线 （共 31 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol T=20°C; 2 h;
参考文献
SANTEN PHARMACEUTICAL CO., LTD.
Patent: WO2006/22442 A1, 2006 ;
Location in patent: Page/Page column 56 ;
反应条件
1: T=220°C; 4 h; Inert atmosphere; 2: With potassium carbonate in water T=20°C;
参考文献
Lin, Guo-Wu; Wang, Yue; Jin, Qiao-Mei; Yang, Tao-Tao; Song, Jie-Mei; Lu, Yi; Huang, Qing-Jie; Song, Ke; Zhou, Jun; Lu, Tao
Inorganica Chimica Acta, 2012 , vol. 382, # 1 p. 35 - 42
反应条件
1: With copper(l) iodide; Na2S*9H2O in N,N-dimethyl-formamide T=80°C; 12 h; 2: With hydrogenchloride in N,N-dimethyl-formamide T=20°C;
参考文献
Ma, Dawei; Xue, Peng; Jiang, Yongwen; Xie, Siwei; Zhang, Xiaojing; Dong, Jinhua
Angewandte Chemie, International Edition, 2009 , vol. 48, # 23 p. 4222 - 4225
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=20°C; 24 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide T=150°C; 3 h;
参考文献
Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide T=150°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 46, # 8 p. 1349 - 1351
反应条件
potassium carbonate; tris(dibenzylideneacetone)dipalladium (0) in ethylene glycol dimethyl ether; water T=100°C; Suzuki biaryl coupling; 6 h;
参考文献
Majo, Vattoly J.; Prabhakaran, Jaya; Mann, J. John; Kumar, J. S. Dileep
Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8535 - 8537
反应条件
1: 74 percent / pyridine 2: 90 percent / SnCl2*2H2O / ethanol / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 17 p. 3375 - 3384
反应条件
sulfur T=170 - 190°C;
参考文献
DE75674 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 825
Journal of the American Chemical Society, , vol. 50, p. 434
反应条件
1: 85 percent / 2,4-bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane / hexamethylphosphoric acid triamide / 6 h / 100 °C 2: 90 percent / SnCl2*2H2O / ethanol / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 17 p. 3375 - 3384
