1-(3-氯丙基)-1,3-二氢-3-(1-甲基乙烯基)-2H-苯并咪唑-2-酮合成路线 (共 5 条)
反应条件
in hydrogenchloride; ethanol
参考文献
Janssen Pharmaceutica N.V.
Patent: US4066772 A1, 1978 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Meth-Cohn, Otto; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 261 - 270
反应条件
1: xylene / 3 h / Heating
2: 95 percent / 1.) NaH / dimethylformamide
View Scheme
参考文献
Meth-Cohn, Otto; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 261 - 270
反应条件
1: xylene / 1.5 h / Heating
2: xylene / 3 h / Heating
3: 95 percent / 1.) NaH / dimethylformamide
View Scheme
参考文献
Meth-Cohn, Otto; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 261 - 270
反应条件
hydrogenchloride; potassium iodide; sodium carbonate in acetone
参考文献
Janssen Pharmaceutica N.V.
Patent: US4035369 A1, 1977 ;