3,4-二氢-1H-吡啶并[4,3-b]吲哚-2(5h)-羧酸叔丁酯合成路线 (共 6 条)
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in DMF (N,N-dimethyl-formamide)
T=110°C; 3.5 h;
参考文献
Ruediger, Edward H.; Deon, Daniel H.; Kadow, John F.
Patent: US2005/267130 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
triethylamine in dichloromethane
参考文献
Dossetter, Alexander Graham; Heron, Nicola Murdoch
Patent: US2009/12077 A1, 2009 ;
Location in patent: Page/Page column 30 ;
反应条件
in tetrahydrofuran
T=5 - 20°C;
参考文献
Bonjoch, Josep; Diaba, Faiza; Pages, Lluis; Perez, Daniel; Soca, Lidia; Miralpeix, Montserrat; Vilella, Dolors; Anton, Paquita; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4299 - 4302
反应条件
L-(+)-tartaric acid-urea melt
T=70°C; Fischer Indole Synthesis; 3 h;
参考文献
Gore, Sangram; Baskaran, Sundarababu; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 17 p. 4568 - 4571
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol; water / 24 h / 70 °C / 760.05 Torr
2: tetrahydrofuran / 8 h / Inert atmosphere; Reflux
View Scheme
参考文献
Kalin, Jay H.; Butler, Kyle V.; Akimova, Tatiana; Hancock, Wayne W.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 639 - 651
反应条件
1: sulfuric acid / 1,4-dioxane / 2 h / 60 °C
2: palladium 10 on activated carbon; hydrogen / ethanol; water / 24 h / 70 °C / 760.05 Torr
3: tetrahydrofuran / 8 h / Inert atmosphere; Reflux
View Scheme
参考文献
Kalin, Jay H.; Butler, Kyle V.; Akimova, Tatiana; Hancock, Wayne W.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 639 - 651