1: With potassium carbonate; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in DMF (N,N-dimethyl-formamide); water
T=80°C;
2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water
1 h;
参考文献
LICA PHARMACEUTICALS A/S
Patent: WO2003/97574 A2, 2003 ;
Location in patent: Page/Page column 32 ;
