2-氯-5-甲氧基苯甲酸合成路线 （共 31 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 21 h; Heating / reflux; 2: With hydrogenchloride in water pH=1;
参考文献
WO2008/64432 A1, ;
Page/Page column 59-60 ;
WO 2008/064432 A1
反应条件
potassium permanganate in water 4 h; Heating / reflux;
参考文献
US2004/97493 A1, ;
Page/Page column 27 ;
反应条件
1: 2-bromo-1-chloro-4-methoxybenzene With n-butyllithium in tetrahydrofuran; hexanes T=-78 - -60°C; 0.25 h; 2: carbon dioxide in tetrahydrofuran; hexanes T=-78 - 20°C; 1.5 h; 3: With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate more than 3 stages;
参考文献
WO2006/101977 A2, ;
Page/Page column 64-65 ;
WO 2006/101977 A2
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide) 16 h;
参考文献
US2005/80074 A1, ;
Page/Page column 33-34 ;
反应条件
hydrogenchloride pH=1;
参考文献
Organic Letters, , vol. 7, # 12 p. 2445 - 2448
反应条件
1: s-BuLi; TMEDA; hexachloroethane / tetrahydrofuran / 0.5 h / -30 °C 2: 0.102 g / aq. HCl / 20 °C / pH 1 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 9 p. 3419 - 3429
反应条件
1: 75 percent / lithium 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - 20 °C 2: s-BuLi; TMEDA; hexachloroethane / tetrahydrofuran / 0.5 h / -30 °C 3: 0.102 g / aq. HCl / 20 °C / pH 1 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 9 p. 3419 - 3429
反应条件
1: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; potassium bromide in ethyl acetate T=5 - 20°C; pH=8.0 - 10.0; 1 h; 2: With hydrogenchloride; sodium chlorite in ethyl acetate T=20°C; pH=5.0; 3 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 51, # 7 p. 888 - 889
反应条件
1: sulfuric acid / Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1599,1601
反应条件
1: sodium sulfate; water; hydroxylamine hydrochloride 2: sulfuric acid / Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1599,1601
