反应条件
1: 1.) n-BuLi / 1) THF, hexane, -78 deg C, 15 min; 2) THF, hexane, rt, several h
2: 1.) Mg, 1,2-dibromotetrafluoroethane / 1) THF, 1 h; 2) THF, 50-60 deg C, 4-6 h
3: 1.) H2SO4, 2.) H2 / 2.) Pd/C / 1) EtOH, reflux, overnight; 2) EtOH, rt, 4 h
View Scheme
参考文献
Hutchings, Richard H.; Meyers
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 1004 - 1013
