N-[4-(1-烯丙基-3-丁基-2,6-二氧代-2,3,6,7-四氢-1H-嘌呤-8-基甲基)苯基]乙酰胺合成路线 （共 6 条）
反应条件
sodium hydroxide in methanol
T=50°C;
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1.1: aq. NaNO2; HOAc
1.2: Na2S2O4; NH4OH / 85 - 95 °C
2.1: EDCI; imidazole
2.2: DMAP / dimethylformamide
3.1: aq. NaOH / methanol / 50 °C
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1.1: EDCI; imidazole
1.2: DMAP / dimethylformamide
2.1: aq. NaOH / methanol / 50 °C
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1: sodium dithionite; ammonium hydroxide / water / 95 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C
3: sodium hydroxide / methanol; water / 50 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2003/106459 A1, 2003 ;
反应条件
1.1: EDCI; imidazole
1.2: DMAP / dimethylformamide
2.1: aq. NaOH / methanol / 50 °C
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1.1: HMDS; (NH4)2SO4 / Heating
1.2: Heating
2.1: aq. NaNO2; HOAc
2.2: Na2S2O4; NH4OH / 85 - 95 °C
3.1: EDCI; imidazole
3.2: DMAP / dimethylformamide
4.1: aq. NaOH / methanol / 50 °C
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
