(+)-二乙酰基-L-酒石酸酐合成路线 （共 13 条）
反应条件
sulfuric acid Heating;
参考文献
Mravik, Andras; Boecskei, Zsolt; Keszei, Sandor; Elekes, Ferenc; Fogassy, Elemer
Tetrahedron Asymmetry, 1996 , vol. 7, # 5 p. 1477 - 1484
反应条件
sulfuric acid in water T=120°C; 0.166667 h;
参考文献
Huang, Huiming; Chen, Dan; Li, Shaohua; Liu, Chengmei
Letters in Organic Chemistry, 2010 , vol. 7, # 2 p. 155 - 158
反应条件
sulfuric acid 0.166667 h; Heating;
参考文献
Dobashi, Yasuo; Hara, Shoji
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2490 - 2496
反应条件
in acetic acid T=50°C;
参考文献
Tomori, Hiroshi; Maruyama, Hiroshi; Ogura, Katsuyuki
Heterocycles, 1996 , vol. 43, # 2 p. 415 - 423
参考文献
European Journal of Organic Chemistry, , # 24 p. 4137 - 4142
反应条件
in acetic acid 3 h; Heating;
参考文献
El-Nezhawy, Ahmed O. H.; El-Diwani, Hoda I.; Schmidt, Richard R.
European Journal of Organic Chemistry, 2002 , # 24 p. 4137 - 4142
反应条件
1: CH2Cl2 / 1.) 0 to 10 deg C, 30 min, 2.) RT, 30 min 2: 1.) 30percent HBr, 2.) Ac2O, 3.) H2 / 3.) 5percent Pd/C / 1.) acetic acid, 50 deg C, 21.5 h, 2.) 50 deg C, 5.5 h, 3.) dioxane, water, 2 atm, 30 min View Scheme
参考文献
Heterocycles, , vol. 43, # 2 p. 415 - 423
反应条件
1: Licarbazepine With pyridine in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2,5-dioxotetrahydrofuran-3,4-diyldiacetate in ethyl acetate T=30 - 35°C; 1 h; Overall yield = 77.08 percent; Overall yield = 0.7 g; Further stages;
参考文献
RANBAXY LABORATORIES LIMITED; HIRPARA, Ketan; KHANDURI, Chandra, Has; SHARMA, Mukesh, Kumar
Patent: WO2013/8194 A2, 2013 ;
Location in patent: Page/Page column 13 ;
反应条件
1: Licarbazepine With pyridine in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2,5-dioxotetrahydrofuran-3,4-diyldiacetate in ethyl acetate T=30 - 35°C; 1 h; Overall yield = 77.08 percent; Overall yield = 0.7 g; Further stages;
参考文献
WO2013/8194 A2, ;
Page/Page column 13 ;
反应条件
chloroform und Behandeln der in wss.Natronlauge loeslichen Anteile des danach isolierten Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Pressman; Bryden; Pauling
Journal of the American Chemical Society, 1948 , vol. 70, p. 1354
