3-氧代-3-(3-吡啶基)丙酸乙酯合成路线 （共 29 条）
参考文献
Balicki, Roman; Nantka-Namirski, Pawel
Polish Journal of Chemistry, 1982 , vol. 56, # 7/8/9 p. 963 - 973
参考文献
Balicki, Roman; Nantka-Namirski, Pawel
Polish Journal of Chemistry, 1982 , vol. 56, # 7/8/9 p. 963 - 973
反应条件
1: aqueous NaOH; NaNO2
2: ethanol; SnCl2+2 H2O; concentrated aqueous HCl
3: palladium; aqueous HCl / Hydrogenation
View Scheme
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
anschliessend Erhitzen des Produkts mit wss. HCl;
参考文献
Merz; Barchet
Archiv der Pharmazie (Weinheim, Germany), 1964 , vol. 297, p. 422,430
反应条件
trifluoromethylsulfonic anhydride; triethylamine; triphenyl-phosphine oxide in 1,2-dichloro-ethane
T=85°C; 2 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad
Patent: WO2012/67664 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
water; hydrogen bromide; bromine
Anschliessenden Erwaermen;
参考文献
Sarodnick; Kempter
Pharmazie, 1985 , vol. 40, # 6 p. 384 - 387
参考文献
Legrand; Lozac'h
Bulletin de la Societe Chimique de France, 1955 , p. 79,83
反应条件
Pd-BaSO4; perchloric acid; acetic acid
参考文献
Graef et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 257,263
反应条件
ethanol; potassium ethanolate
参考文献
Sugasawa et al.
Pharmaceutical Bulletin, 1954 , vol. 2, p. 39
