2-(8-氟咪唑并[1,2-a]吡啶-7-基)丙烷-2-醇合成路线 （共 3 条）
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C
1.2: 95 percent / tetrahydrofuran / -78 - 20 °C
2.1: Cs2CO3; BINAP; Pd(OAc)2 / toluene / 95 °C
3.1: aq. HBr / 90 °C
4.1: propan-2-ol / 50 °C
View Scheme
参考文献
Humphries, Alexander C.; Gancia, Emanuela; Gilligan, Myra T.; Goodacre, Simon; Hallett, David; Merchant, Kevin J.; Thomas, Steve R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1518 - 1522
反应条件
1: Cs2CO3; BINAP; Pd(OAc)2 / toluene / 95 °C
2: aq. HBr / 90 °C
3: propan-2-ol / 50 °C
View Scheme
参考文献
Humphries, Alexander C.; Gancia, Emanuela; Gilligan, Myra T.; Goodacre, Simon; Hallett, David; Merchant, Kevin J.; Thomas, Steve R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1518 - 1522
反应条件
in isopropyl alcohol
T=50°C;
参考文献
Humphries, Alexander C.; Gancia, Emanuela; Gilligan, Myra T.; Goodacre, Simon; Hallett, David; Merchant, Kevin J.; Thomas, Steve R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1518 - 1522
