2-溴-5-(4-甲基哌嗪-1-基)苯甲醛合成路线 （共 3 条）
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 0.166667 h;
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: p-TsOH / toluene / 18 h / Heating
2: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C
3: 17 g / aq. HCl / toluene / 2 h / 25 °C
4: 95 percent / NBS / CH2Cl2 / 0.17 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C
2: 17 g / aq. HCl / toluene / 2 h / 25 °C
3: 95 percent / NBS / CH2Cl2 / 0.17 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
