2-氨基-6-硝基苯并噻唑合成路线 （共 40 条）
反应条件
1: SnCl2*2H2O / ethanol / Heating
2: tetrahydrofuran
View Scheme
参考文献
Patman, Joanne; Bhardwaj, Namrta; Ramnauth, Jailall; Annedi, Subhash C.; Renton, Paul; Maddaford, Shawn P.; Rakhit, Suman; Andrews, John S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2540 - 2544
反应条件
1: SnCl2*2H2O / ethanol / Heating
2: tetrahydrofuran
3: aq. NaOH / tetrahydrofuran
View Scheme
参考文献
Patman, Joanne; Bhardwaj, Namrta; Ramnauth, Jailall; Annedi, Subhash C.; Renton, Paul; Maddaford, Shawn P.; Rakhit, Suman; Andrews, John S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2540 - 2544
反应条件
in chloroform
T=0 - 5°C; 3 h;
参考文献
Amnerkar, Nikhil D.; Bhusari, Kishore P.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 149 - 159
参考文献
Pandeya; Yadav, Meena K.; Mishra, Vaishali; Srivastava, Shobhit; Singh, Bal Krishna
Asian Journal of Chemistry, 2011 , vol. 23, # 7 p. 3003 - 3007
反应条件
1: phosphoric acid; sodium nitrite; copper(II) sulfate; sodium chloride
2: triethylamine / dichloromethane
3: zinc; acetic acid / ethanol / 0.5 h / |Reflux
View Scheme
参考文献
Avila, Belem; Roth, Aaron; Streets, Heather; Kurth, Mark J.; Dwyer, Donard S.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5976 - 5978,3
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=25°C; 18 h;
参考文献
Yoshida, Masao; Hayakawa, Ichiro; Hayashi, Noriyuki; Agatsuma, Toshinori; Oda, Youko; Tanzawa, Fumie; Iwasaki, Shiho; Koyama, Kumiko; Furukawa, Hidehiko; Kurakata, Shinichi; Sugano, Yuichi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3328 - 3332
反应条件
1: 92 percent / DMAP / CH2Cl2 / 18 h / 25 °C
2: 91 percent / H2 / Pd/C / tetrahydrofuran / 13 h / 25 °C
View Scheme
参考文献
Liu, Yang; Wang, Yan; Dong, Guoqiang; Zhang, Yongqiang; Wu, Shanchao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
MedChemComm, 2013 , vol. 4, # 12 p. 1551 - 1561
反应条件
pyridine
0.333333 h; RefluxMicrowave irradiation;
参考文献
Laddha, Sachin S.; Bhatnagar, Satyendra P.
Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 9 p. 2262 - 2273
参考文献
Takahashi; Okada
Yakugaku Zasshi, 1951 , vol. 71, p. 423
Chem.Abstr., 1952 , p. 4531
反应条件
(i) NaNO2, H2SO4, aq. AcOH, (ii) /BRN= 507140/, aq. NaOAc; Multistep reaction;
参考文献
Yagupol'skii,L.M.; Gandel'sman,L.Z.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 2301 - 2307,2240 - 2245
