反应条件
1: 1 h / Heating 2: Na2CO3 / butan-1-ol / 1.5 h / Heating 3: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 4: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 5: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 6: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 7: 40 percent / hydroxybenztriazole / dimethylformamide / 1.) 0 deg C, 1.5 h, 2.) RT, 2 d View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 746 - 751
