1: 2-Chloro-3-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 3.33333 h; 2: carbon dioxide in tetrahydrofuran; n-heptane; ethylbenzene T=0°C; 1.33333 h; 3: With hydrogenchloride in water pH=2;

1: With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=0°C; 0.166667 h;

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C 2.2: NH2 cartridge View Scheme